383473

3-Formyl-6-methylchromone

97%

• Synonym(s): 6-Methyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde
• Empirical Formula (Hill Notation): C₁₁H₈O₃
• CAS Number: 42059-81-4
• Molecular Weight: 188.18
• MDL number: MFCD00138943
• UNSPSC Code: 12352100
• PubChem Substance ID: 24863971
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 97%
• form: solid
• mp: 172-173 °C (lit.)
• functional group: aldehyde; ketone
• SMILES string: Cc1ccc2OC=C(C=O)C(=O)c2c1
• InChI: 1S/C11H8O3/c1-7-2-3-10-9(4-7)11(13)8(5-12)6-14-10/h2-6H,1H3
• InChI key: GBWMIOYSMWCYIZ-UHFFFAOYSA-N

Description

General description

3-Formyl-6-methylchromone is a 3-formyl-substituted chromone. The combustion calorimetric estimation of the enthalpy of combustion of 3-formyl-6-methylchromone has been reported. Its anti-proliferative action on the MDR human colon cancer and mouse lymphoma has been investigated.

Application

3-Formyl-6-methylchromone has been used for the synthesis of 3-formyl-6-methylchromone-4-phenylthiosemicarbazone.

3-Formyl-6-methylchromone may be used in the preparation of series of Schiff′s bases, via reaction with aromatic sulfonamides, such as sulfanilamide, homosulfanilamide, 4-aminoethyl-benzenesulfonamide, a pyrimidinyl-substituted sulfanilamide derivative, sulfaguanidine and 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide. It may be used in the preparation of Schiff base, which undergoes addition reaction with diethyl phosphite to afford bis[(1,2,4,3-triazaphospholyl)(chromonyl)aminomethylphosphonate] derivative and bis[(1,2,4,3-triazaphospholyl)(chromonyl)phosphorylamino-methylphosphonate] derivative.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves