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Structure-activity study of phosphoramido acid esters as acetylcholinesterase inhibitors.

Journal of enzyme inhibition and medicinal chemistry (2008-07-31)
Saied Ghadimi, Ali Asghar Ebrahimi Valmoozi, Mehrdad Pourayoubi, Keyvan Asad Samani
ZUSAMMENFASSUNG

Phosphoramido acid esters (CH(3))(2)NP(O)X(p-OC(6)H(4)-CH(3)) (containing P-Cl (1), P-O (2), P-F (3), P-CN (5), and P-N (4,6) bonds, X for 2, 4 and 6 is OCH(3), (C(2)H(5))(2)N and morpholin) have been synthesized to investigate the structure-activity study of AChE enzyme inhibition, through the parameters logP, delta(31)P and IC(50). After their characterization by (31)P, (31)P{(1)H}, (13)C, (1)H NMR, IR and mass spectroscopy, the parameters logP and delta(31)P ((31)P chemical shift in NMR) were used to evaluated the lipophilicity and electronical properties. The ability of compounds to inhibit human AChE was predicted by PASS software (version 1.193), and experimentally evaluated by a modified Ellman's assay.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
Acetylcholinesterase aus Humanerythrocyten, buffered aqueous solution, ≥500 units/mg protein (BCA)