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  • Changes in cortical protein markers of iron transport with gender, major depressive disorder and suicide.

Changes in cortical protein markers of iron transport with gender, major depressive disorder and suicide.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2018-12-05)
Brian Dean, Andrew Tsatsanis, Linh Q Lam, Elizabeth Scarr, James A Duce
ZUSAMMENFASSUNG

Objectives: The objective of this study was to determine whether a breakdown in proteins regulating cortical iron homeostasis could be involved in the pathophysiology of mood disorders.Methods: Levels of select proteins responsible for cortical iron transport were quantitated by Western blotting of Brodmann's (BA) areas 6 and 10 from patients with major depressive disorder (n = 13), bipolar disorder (n = 12) and age/sex matched controls (n = 13).Results: We found the inactive form of ceruloplasmin was lower in BA 6 from males compared to females. Levels of copper containing ceruloplasmin was lower in BA 6 from suicide completers whilst levels of amyloid precursor protein, TAU and transferrin were higher in BA 10 from those individuals. The level of prion protein was lower in BA 6 from subjects with major depressive disorder.Conclusions: Our data suggests that perturbation in cortical iron transport proteins is not prevalent in mood disorders. By contrast, our data suggests changes in iron transport proteins in BA 6 and BA 10 are present after suicide completion. If these changes were present before death, they could have had a role in the genesis of the contemplation and completion of suicide.