Direkt zum Inhalt
Merck
  • Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model.

Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model.

Scientific reports (2020-06-14)
Hyung Woo Park, Chun Gwon Park, Min Park, Seung Ho Lee, Hye Ran Park, Jaesung Lim, Sun Ha Paek, Young Bin Choy
ZUSAMMENFASSUNG

Parkinson's disease is a neurodegenerative disorder, and no treatment has been yet established to prevent disease progression. Coenzyme Q10, an antioxidant, has been considered a promising neuroprotective agent; however, conventional oral administration provides limited efficacy due to its very low bioavailability. In this study, we hypothesised that continuous, intrastriatal administration of a low dose of Coenzyme Q10 could effectively prevent dopaminergic neuron degeneration. To this end, a Parkinson's disease rat model induced by 6-hydroxydopamine was established, and the treatment was applied a week before the full establishment of this disease model. Behavioural tests showed a dramatically decreased number of asymmetric rotations in the intrastriatal Coenzyme Q10 group compared with the no treatment group. Rats with intrastriatal Coenzyme Q10 exposure also exhibited a larger number of dopaminergic neurons, higher expression of neurogenetic and angiogenetic factors, and less inflammation, and the effects were more prominent than those of orally administered Coenzyme Q10, although the dose of intrastriatal Coenzyme Q10 was 17,000-times lower than that of orally-administered Coenzyme Q10. Therefore, continuous, intrastriatal delivery of Coenzyme Q10, especially when combined with implantable devices for convection-enhanced delivery or deep brain stimulation, can be an effective strategy to prevent neurodegeneration in Parkinson's disease.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
Anti-Laminin in Kaninchen hergestellte Antikörper, 0.5 mg/mL, affinity isolated antibody, buffered aqueous solution
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
6-Hydroxydopamin -hydrochlorid, ≥97% (titration), powder
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Anti-Nestin-Antikörper, Klon 401 (Ratte), clone rat-401, Chemicon®, from mouse
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Anti-Tyrosinhydroxylase-Antikörper, Klon 2/40/15, clone 2/40/15, Chemicon®, from mouse
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Anti-Glial fibrillary acidic protein δ Antibody, serum, Chemicon®
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge