649317

(R)-(+)-2-Methyl-CBS-Oxazaborolidin

• Synonym(e): (R)-1-Methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole, (R)-Me-Corey-Bakshi-Shibata catalyst
• Empirische Formel (Hill-System): C₁₈H₂₀BNO
• CAS-Nummer: 112022-83-0
• Molekulargewicht: 277.17
• MDL-Nummer: MFCD00078440
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 24883644
• NACRES: NA.22

Eigenschaften

• Assay: ≥90%
• Form: solid
• mp (Schmelzpunkt): 85-95 °C (lit.)
• SMILES String: CB1OC(C2CCCN12)(c3ccccc3)c4ccccc4
• InChI: 1S/C18H20BNO/c1-19-20-14-8-13-17(20)18(21-19,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17H,8,13-14H2,1H3/t17-/m1/s1
• InChIKey: VMKAFJQFKBASMU-QGZVFWFLSA-N

Beschreibung

Anwendung

The CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst has been used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C₂ symmetrical ferrocenyl diols, and propargyl alcohols.

CBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H302,H318
• P-Sätze: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Dam. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)