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Merck

PTPN6

protein tyrosine phosphatase, non-receptor type 6

Synonyme:
HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(5777) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(15170) protein tyrosine phosphatase, non-receptor type 6
  • Rat(116689) protein tyrosine phosphatase, non-receptor type 6
  • domestic guinea pig(100723417) protein tyrosine phosphatase, non-receptor type 6
  • naked mole-rat(101725029) protein tyrosine phosphatase, non-receptor type 6
  • Domestic Rabbit(100348648) protein tyrosine phosphatase, non-receptor type 6
  • cow(512312) protein tyrosine phosphatase, non-receptor type 6
  • sheep(101108643) protein tyrosine phosphatase, non-receptor type 6
  • Zebrafish(335573) protein tyrosine phosphatase, non-receptor type 6
  • chicken(427947) protein tyrosine phosphatase, non-receptor type 6
  • Horse(100052882) protein tyrosine phosphatase, non-receptor type 6
  • domestic cat(101087073) protein tyrosine phosphatase, non-receptor type 6
  • dog(486717) protein tyrosine phosphatase, non-receptor type 6

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-SHP-1/PTPN6 Antibody, clone 1D20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human, monkey
Anwendung
affinity binding assay
immunofluorescence

immunohistochemistry

western blot
Anti-PTPN6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human, rat
Anwendung
immunofluorescence
immunohistochemistry

western blot
Anti-phospho-SHP-1 (pTyr536) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry

western blot
Anti-phospho-SHP-1 (pTyr564) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
western blot
Anti-SHP-1 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
2-Bromacetophenon, 98%,
Spezies
human
Bromessigsäure, reagent grade, 97%,
Spezies
human
2-Brom-4′-methoxy-acetophenon, 97%,
Spezies
human
2-Chlor-acetophenon, 98%,
Spezies
human
2-Brom-4′-fluor-acetophenon, 97%,
Spezies
human

Proteins

Produktnummer
Beschreibung
Spezies
SHP-1 Active human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Spezies
human
PTPN6, active, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human PTPN6,
Spezies
human
MISSION® esiRNA, targeting mouse Ptpn6,
Spezies
mouse