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KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

Synonyme:
DFNA2, DFNA2A, KV7.4
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(9132) Summary: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(60613) potassium voltage-gated channel, subfamily Q, member 4
  • Rat(298496) potassium voltage-gated channel, KQT-like subfamily, member 4
  • sheep(101122655) potassium voltage-gated channel, KQT-like subfamily, member 4
  • Domestic Rabbit(100358271) potassium voltage-gated channel, KQT-like subfamily, member 4
  • domestic guinea pig(100716024) potassium voltage-gated channel, KQT-like subfamily, member 4
  • naked mole-rat(101714294) potassium voltage-gated channel, KQT-like subfamily, member 4
  • chicken(419643) potassium voltage-gated channel, KQT-like subfamily, member 4
  • domestic cat(101091641) potassium voltage-gated channel, KQT-like subfamily, member 4
  • Horse(100067963) potassium voltage-gated channel, KQT-like subfamily, member 4
  • cow(528741) potassium voltage-gated channel, KQT-like subfamily, member 4
  • dog(482451) potassium voltage-gated channel, KQT-like subfamily, member 4

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Small Molecule - Activator

Produktnummer
Beschreibung
Spezies
BMS 204352, ≥98% (HPLC),
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Monoclonal Anti-KCNQ4 antibody produced in mouse, clone 2H6, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
mouse
Anwendung
ELISA
western blot
Anti-KCNQ4 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
western blot

Small Molecule - Blocker

Produktnummer
Beschreibung
Spezies
Retigabin, analytical standard,
Spezies
human
Guanidin -hydrochlorid, for molecular biology, ≥99%,
Spezies
human
Guanidin -hydrochlorid, ≥98%,
Spezies
human
Guanidin -hydrochlorid, ≥99% (titration), organic base and chaeotropic agent,
Spezies
human
Guanidin -hydrochlorid, ,
Spezies
human

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
N-Ethylmaleimid, crystalline, ≥98% (HPLC),
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human KCNQ4,
Spezies
human
MISSION® esiRNA, targeting mouse Kcnq4,
Spezies
mouse