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EGFR

epidermal growth factor receptor

Synonyme:
ERBB, ERBB1, HER1, PIG61, mENA
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(1956) Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13649) epidermal growth factor receptor
  • Rat(24329) epidermal growth factor receptor
  • fruit fly(37455) Epidermal growth factor receptor
  • cow(407217) epidermal growth factor receptor
  • Horse(100067755) epidermal growth factor receptor
  • domestic cat(100510799) epidermal growth factor receptor
  • dog(404306) epidermal growth factor receptor
  • chicken(396494) epidermal growth factor receptor
  • domestic guinea pig(100725363) epidermal growth factor receptor
  • naked mole-rat(101723771) epidermal growth factor receptor
  • sheep(780479) epidermal growth factor receptor

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ELISA

Produktnummer
Beschreibung
Spezies
Human EGFR / ErbB1 ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Spezies
human
Cell-Based ELISA for detecting phospho-EGFR, in cultured cell lines, 96 assays,
Spezies
human
Phospho-EGFR (pTyr1068) and pan-EGFR ELISA Kit, for detection of human phospho-egfr (pTyr1068) and pan-egfr in cell and tissue lysates,
Spezies
human
Phospho-EGFR (pTyr1068) ELISA Kit, for detection of human phospho-egfr (pTyr1068) in cell and tissue lysates,
Spezies
human
Mouse EGFR ELISA, for serum, plasma and cell culture supernatants,
Spezies
mouse

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
Tyrphostin AG 1478, ≥98%,
Spezies
human, mouse
SU 5416, ≥98% (HPLC),
Spezies
human, mouse
Genistein, synthetic, ≥98% (HPLC), powder,
Spezies
mouse, human, rat
Genistein, from Glycine max (soybean), ~98% (HPLC),
Spezies
mouse, human, rat

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Monoclonal Anti-EGFR PE produced in mouse, ,
Speziesreaktivität
horse
Anwendung
flow cytometry
Anti-EGFRvIII Antibody, clone DH8.3, clone DH8.3, from mouse,
Speziesreaktivität
human
Anwendung
ELISA
flow cytometry

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-EGFR Antibody, clone LA22, clone LA22, Upstate®, from mouse,
Speziesreaktivität
human
Anwendung
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-EGFR-Antikörper, neutralisierend, Klon LA1, clone LA1, Upstate®, from mouse,
Speziesreaktivität
human
Anwendung
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

neutralization

western blot
Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal, clone C-273, purified from hybridoma cell culture,
Speziesreaktivität
drosophila
Anwendung
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
Gefitinib, ≥98% (HPLC),
Spezies
human
Erlotinib hydrochloride, ,
Spezies
human
DAPH, ≥98% (HPLC), solid,
Spezies
human
Tyrphostin 1, ≥98%,
Spezies
human
PKI-166, ≥98% (HPLC),
Spezies
human

Proteins

Produktnummer
Beschreibung
Spezies
Epidermal Growth Factor Receptor human, lyophilized powder, ≥15,000 units/mg protein (Bradford),
Spezies
human
EGFR Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Spezies
human
EGFR (T790M L858R) Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Spezies
human
EGF-receptor human, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Spezies
human
Epidermal Growth Factor Receptor human, buffered aqueous glycerol solution, 5,000-30,000 units/mg protein (Lowry),
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human EGFR,
Spezies
human
MISSION® esiRNA, targeting mouse Egfr,
Spezies
mouse