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Merck

CDKN2A

cyclin-dependent kinase inhibitor 2A

Synonyme:
ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16
Spezies:
Human CDKN2A (1029), Mouse Cdkn2a (12578), Rat Cdkn2a (25163), chicken CDKN2A (395077), dog CDKN2A (100271861), cow CDKN2A (616369), domestic cat CDKN2A (101089220), domestic guinea pig Cdkn2a (100731972)
UniProtKB-ID:
P42771, A5X2G7, D3DRK1, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05
Gen-ID:
  • Human(1029) Summary: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
  • Mouse(12578) cyclin-dependent kinase inhibitor 2A
  • Rat(25163) cyclin-dependent kinase inhibitor 2A
  • chicken(395077) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
  • dog(100271861) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
  • cow(616369) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
  • domestic cat(101089220) cyclin-dependent kinase inhibitor 2A
  • domestic guinea pig(100731972) cyclin-dependent kinase inhibitor 2A

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
ZRB1437
Anti-p16-INK4a Antibody, clone 5F22 Antibody, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human, mouse
Anwendung
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
SAB4500072
Anti-p16 INK antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse
Anwendung
ELISA
western blot
SAB5700620
Anti-CDKN2A/p16INK4a antibody produced in rabbit, ,
Speziesreaktivität
human, mouse, rat
Anwendung
immunofluorescence
immunohistochemistry
western blot
SAB56000308
p16 INK4a Rabbit Monoclonal Antibody, clone RM409, affinity purified immunoglobulin,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
MAB4133
Anti-p16 Antibody, clone D25, clone D25, Chemicon®, from mouse,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
R7772
Roscovitine, ≥98% (TLC),
Spezies
human, mouse, rat
O0886
Olomoucine, ≥98% (HPLC),
Spezies
human, rat

Proteins

Produktnummer
Beschreibung
Spezies
SRP3134
p16-INK-4a human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Spezies
human
SRP3135
p16-INK-4a TAT human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
EHU900921
MISSION® esiRNA, targeting human CDKN2A,
Spezies
human