- Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.
Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.
Antimicrobial agents and chemotherapy (2012-05-23)
Yasuhiro Horita, Takemasa Takii, Tetsuya Yagi, Kenji Ogawa, Nagatoshi Fujiwara, Emi Inagaki, Laurent Kremer, Yasuo Sato, Ryuji Kuroishi, Yoosa Lee, Toshiaki Makino, Hajime Mizukami, Tomohiro Hasegawa, Ryuji Yamamoto, Kikuo Onozaki
PMID22615274
RESUMEN
The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB.
MATERIALES
Product Number
Marca
Descripción del producto
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Supelco
Sodium diethyldithiocarbamate trihydrate, ACS reagent, for the determination and separation of heavy metals, ≥97%
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad