- Sphingosine in apoptosis signaling.
Sphingosine in apoptosis signaling.
Biochimica et biophysica acta (2003-01-18)
Olivier Cuvillier
PMID12531549
RESUMEN
The sphingolipid metabolites ceramide, sphingosine, and sphingosine 1-phosphate contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite sphingosine act as negative regulators of cell proliferation and promote apoptosis. Conversely, sphingosine 1-phosphate, formed by phosphorylation of sphingosine by a sphingosine kinase, has been involved in stimulating cell growth and inhibiting apoptosis. As the phosphorylation of sphingosine diminishes apoptosis, while dephosphorylation of sphingosine 1-phosphate potentiates it, the role of sphingosine as a messenger of apoptosis is of importance. Herein, the effects of sphingosine on diverse signaling pathways implicated in the apoptotic process are reviewed.
MATERIALES
Referencia del producto
Marca
Descripción del producto
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad