V3639

Valinomycin

Ready Made Solution, ~1 mg/mL in DMSO

• Sinónimos: Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)₃: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
• Fórmula empírica (notación de Hill): C₅₄H₉₀N₆O₁₈
• Número de CAS: 2001-95-8
• Peso molecular: 1111.32
• Beilstein/REAXYS Number: 78657
• MDL number: MFCD00005114
• UNSPSC Code: 51102829
• PubChem Substance ID: 24900743
• NACRES: NA.76

Propiedades

• biological source: Streptomyces sp.
• Quality Level: 200
• assay: ≥90% (HPLC)
• form: liquid
• storage condition: (Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)
• concentration: ~1 mg/mL in DMSO
• color: colorless
• antibiotic activity spectrum: Gram-positive bacteria; parasites; viruses
• mode of action: cell membrane | interferes
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
• InChI: 1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
• InChI key: FCFNRCROJUBPLU-RPUZOQEISA-N

Descripción

General description

Chemical structure: peptide

Application

Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.

Biochem/physiol Actions

K⁺-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.

Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 188.6 °F - closed cup
• flash_point_c: 87 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter