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Merck
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Key Documents

T0953

Sigma-Aldrich

14-3-3 Tau/Theta histidine-tagged human

recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:

14-3-3 tau, 14-3-3 theta, 14-3-3t, 1C5, Bap1, HS1, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide, YWHAQ

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About This Item

UNSPSC Code:
12352200

recombinant

expressed in E. coli

Quality Level

200

assay

≥90% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~30 kDa (14-3-3 proteins)

UniProt accession no.

P27348

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... YWHAQ(10971)

Biochem/physiol Actions

14-3-3 proteins are involved in a multitude of biological processes and play a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control. Co-immunoprecipitation experiments demonstrate the interaction of 14-3-3 τ/θ adaptor protein with various proteins (UCP3, PKCζ). 14-3-3 τ/θ is involved in cell cycle arrest and cellular differentiation. 14-3-3 τ/θ plays an active role in mediating Vpr-induced cell cycle arrest in human T cells.

Physical form

Supplied as a 0.2 μm filtered solution in 50 mM Tris-HCl, pH 7.6, 1 mM EDTA, 1 mM DTT, and 20% glycerol (w/v).

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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14-3-3 isotypes facilitate coupling of protein kinase Cζ to Raf-1: negative regulation by 14-3-3 phosphorylation.
Van Der Hoeven, P.C., et al.
The Biochemical Journal, 15, 297-306 (2000)
Mathematical biology in Biology Direct.
Andrei Yakovlev
Biology direct, 3, 1-1 (2008-01-18)
B Pierrat et al.
European journal of biochemistry, 267(9), 2680-2687 (2000-04-28)
Uncoupling proteins (UCPs) are members of the superfamily of the mitochondrial anion carrier proteins (MATP). Localized in the inner membrane of the organelle, they are postulated to be regulators of mitochondrial uncoupling. UCP2 and 3 may play an important role
14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation.
Guri Tzivion et al.
The Journal of biological chemistry, 277(5), 3061-3064 (2001-11-16)
José M A Moreira et al.
Molecular & cellular proteomics : MCP, 7(7), 1225-1240 (2008-04-02)
The 14-3-3 proteins constitute a family of highly conserved and broadly expressed multifunctional polypeptides that are involved in a variety of important cellular processes that include cell cycle progression, growth, differentiation, and apoptosis. Although the exact cellular function(s) of 14-3-3

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