SRP6322

BMP8B human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Sinónimos: BMP8, Bone morphogenetic protein 8B, OP2
• UNSPSC Code: 12352202
• NACRES: NA.32

Propiedades

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥90% (SDS-PAGE)
• form: liquid
• mol wt: 18.1 kDa (162 aa, 264-402 aa + His tag)
• packaging: pkg of 100 μg
• concentration: 1 mg/mL
• UniProt accession no.: P34820
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... BMP8B(656)

Descripción

General description

The BMP8B (bone morphogenetic protein 8b) gene is mapped to human chromosome 1p34.2. It is also expressed in testis germ cell.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-β (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. Recombinant human BMP8B protein, fused to His-tag at N-terminus, was expressed in E.coli.

Biochem/physiol Actions

The BMP8B (bone morphogenetic protein 8b) gene expression prevents cancer cell proliferation and activates cell death. Decreased gene expression is observed in pancreatic cancer. BMP8B mediates the process of placentation, by regulating cell division, differentiation and survival. It prevents glucocorticoid-induced bone cell death.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable