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Merck
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Key Documents

SRP6161

Sigma-Aldrich

FGF-7 human

recombinant, expressed in human cells, ≥95% (SDS-PAGE)

Sinónimos:

Fibroblast growth factor 7, HBGF-7, Heparin-binding growth factor 7, KGF, Keratinocyte growth factor

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in human cells

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

(17 and 30 kDa, monomer, glycosylated)

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

NCBI accession no.

P21781

UniProt accession no.

P21781

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FGF7(2252)

General description

Fibroblast growth factor-7 (FGF-7) is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities. The gene encoding this protein is localized on human chromosome 15q21.1.

Biochem/physiol Actions

Fibroblast growth factor (FGF) family members are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. This protein associates with and activates fibroblast growth factor receptors (FGFRs). Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, re-epithelialization of wounds, hair development and early lung organogenesis.

Physical form

Lyophilized from a PBS solution.

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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PLoS genetics, 10(10), e1004687-e1004687 (2014-10-21)
Epidermal stratification of the mammalian skin requires proliferative basal progenitors to generate intermediate cells that separate from the basal layer and are replaced by post-mitotic cells. Although Wnt signaling has been implicated in this developmental process, the mechanism underlying Wnt-mediated
Krijn K Dijkstra et al.
Cell, 174(6), 1586-1598 (2018-08-14)
Cancer immunotherapies have shown substantial clinical activity for a subset of patients with epithelial cancers. Still, technological platforms to study cancer T-cell interactions for individual patients and understand determinants of responsiveness are presently lacking. Here, we establish and validate a
The Fibroblast Growth Factor signaling pathway.
Ornitz DM and Itoh N
Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 4(3), 215-266 (2015)
A family-based association study after genome-wide linkage analysis identified two genetic loci for renal function in a Mongolian population.
Park H
Kidney International, 83(2), 285-292 (2013)
Laxmi Yeruva et al.
mBio, 5(3), e01241-e01214 (2014-06-26)
It is not currently possible to predict the probability of whether a woman with a chlamydial genital infection will develop pelvic inflammatory disease (PID). To determine if specific biomarkers may be associated with distinct chlamydial pathotypes, we utilized two Chlamydia
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