SRP0399
Histone H3 peptide (Mono-methylated K9), biotin
≥95% (HPLC)
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Productos recomendados
assay
≥95% (HPLC)
form
aqueous solution
packaging
pkg of 500 μL
concentration
40 μM
shipped in
dry ice
storage temp.
−70°C
General description
Histone H3 peptide mono-methylated at Lysine 9, biotinylated, substrate for histone demethylases belonging to the Jumanji domain-containing (JMJ) family .
Application
Suitable as a substrate for histone demethylases belonging to the Jumonji (JMJ) family. It can be used to study enzyme kinetics, and to screen small molecular inhibitors of these demethylases for drug discovery and HTS applications.
Other Notes
500 μL at 40 μM, or 20 nmol Sold as 500 μL
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
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Shiv I S Grewal et al.
Current opinion in cell biology, 16(3), 230-238 (2004-05-18)
Heterochromatin mediates various nuclear processes including centromere function, gene silencing and nuclear organization. Although it was discovered nearly 75 years ago, the pathways involved in heterochromatin establishment, assembly and epigenetic maintenance have been elusive. Recent reports have demonstrated that distinct
Judd C Rice et al.
Molecular cell, 12(6), 1591-1598 (2003-12-24)
The functional significance of mono-, di-, and trimethylation of lysine residues within histone proteins remains unclear. Antibodies developed to selectively recognize each of these methylated states at histone H3 lysine 9 (H3 Lys9) demonstrated that mono- and dimethylation localized specifically
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