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Merck
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Key Documents

SRP0359

Sigma-Aldrich

NEK6 active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)

Sinónimos:

NIMA (never in mitosis gene a)-related kinase 6, SID6-1512

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥90% (SDS-PAGE)

form

aqueous solution

mol wt

40.1 kDa

packaging

pkg of 10 μg

NCBI accession no.

NM_014397

UniProt accession no.

Q9HC98

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... NEK6(10783)

General description

Human NEK6 (GenBank Accession No. NM_014397), amino acids 1-313 with N-terminal HIS6-tag, MW=40.1 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Unit Definition

One unit is defined as the amount of enzyme that will phosphorylate 1 nmol NEK6 substrate (FLAKSFGSPNRAYKK) per minute at pH 7.4 and 30°C.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Min-Jean Yin et al.
The Journal of biological chemistry, 278(52), 52454-52460 (2003-10-18)
The Aspergillus nidulans protein NIMA (never in mitosis, gene A) is a protein kinase required for the initiation of mitosis, whereas its inactivation is necessary for mitotic exit. Here, we demonstrate that human NIMA-related kinase 6 (Nek6) is required for
Christopher Belham et al.
The Journal of biological chemistry, 278(37), 34897-34909 (2003-07-04)
The Nek family of protein kinases in humans is composed of 11 members that share an amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the control of several aspects of mitosis, and divergent carboxyl-terminal tails of varying
Laura O'Regan et al.
The Journal of cell biology, 209(3), 349-358 (2015-05-06)
Hsp70 proteins represent a family of chaperones that regulate cellular homeostasis and are required for cancer cell survival. However, their function and regulation in mitosis remain unknown. In this paper, we show that the major inducible cytoplasmic Hsp70 isoform, Hsp72

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