SML3833

NB-598

≥98% (HPLC)

• Sinónimos: (E)-3-[(3,3′-Bithiophen)-5-ylmethoxy]-N-(6,6-dimethyl-2-hepten-4-ynyl)- N-ethylbenzylamine, 3-([3,3′-Bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-ethylbenzenemethanamine, NB 598
• Fórmula empírica (notación de Hill): C₂₇H₃₁NOS₂
• Número de CAS: 131060-14-5
• Peso molecular: 449.67
• MDL number: MFCD00898838
• UNSPSC Code: 51111800
• UNSPSC Code: 12352200
• NACRES: NA.21

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C
• SMILES string: [s]1c(cc(c1)c3c[s]cc3)COc2cc(ccc2)CN(CC)C\C=C\C#CC(C)(C)C
• InChI: 1S/C27H31NOS2/c1-5-28(14-8-6-7-13-27(2,3)4)18-22-10-9-11-25(16-22)29-19-26-17-24(21-31-26)23-12-15-30-20-23/h6,8-12,15-17,20-21H,5,14,18-19H2,1-4H3/b8-6+
• InChI key: KIRGLCXNEVICOG-SOFGYWHQSA-N

Descripción

Biochem/physiol Actions

NB-598 is a potent and specific inhibitor of mammalian squalene epoxidase (SQLE) that suppresses triglyceride biosynthesis through the farnesol pathway. It decreases cholesterol levels in cells. NB-598 exhibit potent cytotoxic effects in subset of f neuroendocrine tumors, such as small cell lung cancers through accumulation of toxic squalene with in sensitive cancer cells.

Potent and specific inhibitor of mammalian squalene epoxidase (SQLE) that suppresses triglyceride biosynthesis through the farnesol pathway

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable