SML2309

Oxaphenamide

≥98% (HPLC)

• Sinónimos: 2-Hydroxy-N-(4-hydroxyphenyl)benzamide, 4′-Hydroxysalicylanilide, Osalmide, Oxaphenamide, p-hydroxyphenylsalicylamide
• Fórmula empírica (notación de Hill): C₁₃H₁₁NO₃
• Número de CAS: 526-18-1
• Peso molecular: 229.23
• EC Number: 208-385-9
• MDL number: MFCD00020026
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N(c2ccc(cc2)O)C(=O)c1c(cccc1)O
• InChI: 1S/C13H11NO3/c15-10-7-5-9(6-8-10)14-13(17)11-3-1-2-4-12(11)16/h1-8,15-16H,(H,14,17)
• InChI key: LGCMKPRGGJRYGM-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Osalmid is a potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid inhibits RR (ribonucleotide reductase) activity in vivo, and exhibits synergistic effect with lamivudine on inactivation mutant HBV strain. Osalmid is a biliation activator (choleretic agent), but a mechanism of this activity remains unknown.

potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis; choleretic agent

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3