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SML1741

Sigma-Aldrich

TH1020

≥95% (HPLC)

Sinónimos:

4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3′,2′,4,5]-thieno[3,2-d]pyrimidine, 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine

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About This Item

Fórmula empírica (notación de Hill):
C23H15N7S2
Número de CAS:
1841460-82-9
Peso molecular:
453.54
UNSPSC Code:
51111800
PubChem Substance ID:
329826048
NACRES:
NA.77

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 3 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

C1(C2=CC=NC=C2)=NN=C(SC3=NC=NC4=C3SC5=C4C=CC=N5)N1CC6=CC=CC=C6

Application

TH1020 has been used to inhibit toll-like receptor 5 (TLR5) in porcine intestinal epithelial monolayer cells and mice.

Biochem/physiol Actions

TH1020 is a non-cytotoxic non-cytotoxic toll-like receptor 5 (TLR5)/flagellin complex inhibitor. TH1020 selectively prevents flagellin-induced TLR5 signaling without affecting ligands-induced activation of TLR2, TLR3, TLR4, TLR7 or TLR8.
TH1020 mediates the inhibition of tumor necrosis factor-α (TNF-α) based signaling, It disrupts tetrameric complex by binding the molecular interface between dimeric TLR5.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Lei Yan et al.
ChemMedChem, 11(8), 822-826 (2015-12-05)
Protein-protein interactions have been regarded as "undruggable" despite their importance in many biological processes. The complex formed between host toll-like receptor 5 (TLR5) and flagellin, a globular protein that is the main component of a bacterial flagellum, plays a vital role
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Intrathecal treatment with recombinant high-mobility group box-1 (rHMGB1) in naïve mice leads to a persistent and significantly decreased hind paw withdrawal threshold to mechanical stimuli, suggesting that spinal HMGB1 evokes abnormal pain processing. By contrast, repeated intrathecal treatment with anti-HMGB1

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