SML0786

Decursin

≥97% (HPLC)

• Sinónimos: (+)-Decursin, (7S)-7,8-Dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl 3-methyl-2-butenoate, 3-Methyl-2-butenoic acid (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester
• Fórmula empírica (notación de Hill): C₁₉H₂₀O₅
• Número de CAS: 5928-25-6
• Peso molecular: 328.36
• MDL number: MFCD00272154
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• biological source: Radix peucedani
• Quality Level: 100
• assay: ≥97% (HPLC)
• form: powder
• optical activity: [α]/D +120 to +160°, c = 0.5 in chloroform-d
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
• InChI key: CUKSFECWKQBVED-INIZCTEOSA-N

Descripción

Biochem/physiol Actions

Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. Decursin is potent anti-angiogenic agent targeting the VEGFR-2 signaling pathway. Decursin exhibits potent neuroprotective activity against glutamate and Ab- induced neurotoxicity. Apparently, decursin stimulates activation of Nerf2. Also, decursin inhibits androgen stimulated AR translocation to the nucleus in LNCaP prostate cancer cells.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable