SML0745

NS6180

≥98% (HPLC)

• Sinónimos: 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one
• Fórmula empírica (notación de Hill): C₁₆H₁₂F₃NOS
• Número de CAS: 353262-04-1
• Peso molecular: 323.33
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)c1cc(ccc1)CN2c3c(cccc3)SCC2=O
• InChI: 1S/C16H12F3NOS/c17-16(18,19)12-5-3-4-11(8-12)9-20-13-6-1-2-7-14(13)22-10-15(20)21/h1-8H,9-10H2
• InChI key: ZUIJXKLTUFCDGO-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

NS6180 is a novel inhibitor of the intermediate-conductance Ca2+-activated K+ channel (K_Ca3.1) The IC₅₀ of NS6180 against cloned human K_Ca3.1 is 9 nM. The compound blocks proliferation and production of IL-2 and IFNγ with sub-micromolar potencies in either ConA or PMA/ionomycin challenged rat splenocytes.

Información de seguridad

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H317,H411
• pcodes: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Hazard Classifications: Aquatic Chronic 2 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable