SML0681

Febrifugine dihydrochloride

≥95% (HPLC)

• Sinónimos: 3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride
• Fórmula empírica (notación de Hill): C₁₆H₁₉N₃O₃ · 2HCl
• Número de CAS: 32434-42-7
• Peso molecular: 374.26
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825583
• NACRES: NA.77

Propiedades

• assay: ≥95% (HPLC)
• form: powder
• optical activity: [α]/D 10 to 15°, c = 1 in H₂O
• storage condition: desiccated
• color: off-white to gray-brown
• solubility: H₂O: 15 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C
• InChI: 1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1
• InChI key: SNTOTCUGCWLHEZ-KKJWGQAZSA-N

Descripción

Biochem/physiol Actions

Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.

Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable