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SML0621

Sigma-Aldrich

WZB-117

≥98% (HPLC)

Sinónimos:

3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate), 3-Hydroxy-benzoic acid 1,1′-(3-fluoro-1,2-phenylene) ester

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About This Item

Fórmula empírica (notación de Hill):
C20H13FO6
Número de CAS:
1223397-11-2
Peso molecular:
368.31
MDL number:
MFCD24387113
UNSPSC Code:
12352200
PubChem Substance ID:
329825570
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC(O)=C1)OC2=C(F)C=CC=C2OC(C3=CC(O)=CC=C3)=O

InChI

1S/C20H13FO6/c21-16-8-3-9-17(26-19(24)12-4-1-6-14(22)10-12)18(16)27-20(25)13-5-2-7-15(23)11-13/h1-11,22-23H

InChI key

FRSWCCBXIHFKKY-UHFFFAOYSA-N

Categorías relacionadas

Application

WZB-117 has been used to study its tumor initiating ability in cancer stem cells. It has also been used to study the effect of glucose antagonists on 2-NBDG (2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose) uptake.

Biochem/physiol Actions

WBZ 117 is an inhibitor of basal glucose transport in H1299 lung and other cancer cells.
WBZ 117 is an inhibitor of basal glucose transport.
WZB-117 is an irreversible inhibitor. In cancer cells, WZB-117 prevents cell growth by stimulating apoptosis in any glucose concentration. It targets self-renewal and tumor-initiating capacity in cancer stem cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
116M4621V
036M4617V
035M4620V
033M4601V

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Like tumour cells, during intraerythrocytic stage, Plasmodium-infected erythrocytes rely completely on glucose absorption from the blood circulation for energy metabolism. Glucose is taken up by glucose transporter 1 (GLUT1) on human red blood cells (RBCs) and glucose transporter 4 (GLUT4)
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Astrocytes represent central regulators of brain glucose metabolism and neuronal function. They have recently been shown to adapt their function in response to alterations in nutritional state through responding to the energy state-sensing hormones leptin and insulin. Here, we demonstrate
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Increased glucose metabolism is now recognized as an emerging hallmark of cancer. Recent studies have shown that glucose metabolism is even more active in cancer stem cells (CSCs), a rare population of cancer cells with the capacity to self-renew and

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