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SML0264

Sigma-Aldrich

AEG 3482

≥98% (HPLC)

Sinónimos:

6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

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About This Item

Fórmula empírica (notación de Hill):
C10H8N4O2S2
Número de CAS:
63735-71-7
Peso molecular:
280.33
MDL number:
MFCD02064987
UNSPSC Code:
12352200
PubChem Substance ID:
329825272
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

SMILES string

NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3

InChI

1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)

InChI key

MQUYTXDAVCOCMX-UHFFFAOYSA-N

Biochem/physiol Actions

AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property.
AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
022M4741V

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Amir H Salehi et al.
Chemistry & biology, 13(2), 213-223 (2006-02-24)
We describe a group of small-molecule inhibitors of Jun kinase (JNK)-dependent apoptosis. AEG3482, the parental compound, was identified in a screening effort designed to detect compounds that reduce apoptosis of neonatal sympathetic neurons after NGF withdrawal. We show that AEG3482
Karthiga Santhana Kumar et al.
SpringerPlus, 4, 19-19 (2015-01-28)
Medulloblastoma (MB) comprises four molecularly and genetically distinct subgroups of embryonal brain tumors that develop in the cerebellum. MB mostly affects infants and children and is difficult to treat because of frequent dissemination of tumor cells within the leptomeningeal space.
Zhen Ning Wee et al.
Nature communications, 6, 8746-8746 (2015-10-28)
Metastatic tumour recurrence due to failed treatments remains a major challenge of breast cancer clinical management. Here we report that interleukin-1 receptor-associated kinase 1 (IRAK1) is overexpressed in a subset of breast cancers, in particular triple-negative breast cancer (TNBC), where

Artículos

MAPKs

The mitogen-activated protein kinase (MAPK) family consists of both stress activated (SAPK) and mitogen-activated (MAPK) protein kinases. They form a network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli, including growth factors, chemical or osmotic stress, irradiation, bacterial infection and proinflammatory cytokines.

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