SBVT04
SB-MRP1-Sf9
membrane preparation for Vesicular Transport Assays, recombinant, expressed in baculovirus infected Sf9 cells
Sinónimos:
ABCC1, MRP1, MRP1 humanv membrnae vesicles, Multidrug resistance-associated protein 1
About This Item
Productos recomendados
recombinant
expressed in baculovirus infected Sf9 cells
form
liquid
concentration
5 mg/mL
color
off-white
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... ABCC1(4363)
General description
Application
The standard vesicular transport assay is an inhibitory assay performed with cold test articles. This assay provides information on any interaction between the ABC transporter and the test article. The transport of the reporter substrate is measured in the presence of the test article (typically in 7 concentrations) and IC50 is defined as the concentration inhibiting the transport of the reporter substrate by 50%.
Should radiolabeled form of the investigated compound or adequate analytical methods (LC/MS, HPLC) be available, the vesicular transport assay may be performed in a direct format without the reporter substrate and may identify substrate nature of the test article. The vesicular transport substrate assay is a low throughput assay. It is suitable for low permeability test compounds as high permeability compounds may escape from the vesicles through the lipid bilayer.
PREDIVEZ vesicular transport kit is sold separately. This transporter membrane vesicle assay requires the PREDIVEZ vesicular transport kit and corresponding control membrane below:
SB PREDIVEZ Reagent Kit for MRP1 part number SBPVR2-9RXN and corresponding control membrane SB-beta-gal-Sf9-CTRL part number SBCT03-1EA
Physical form
Legal Information
Related product
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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