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Key Documents

SBR00067

Sigma-Aldrich

Rifampicin Water Soluble

solubility: 50 mg/mL in water, freely soluble

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About This Item

UNSPSC Code:
51283601
NACRES:
NA.76

form

solid

Quality Level

specific activity

(Antibacterial)

solubility

water: freely soluble 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
viruses

mode of action

protein synthesis | interferes

storage temp.

−20°C

General description

Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC). Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease. In addition, Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.

Application

Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.

Biochem/physiol Actions

Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase, which results in cell death.

Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. Inhibits the assembly of DNA and protein into mature virus particles.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Specific packaging of custom RNA molecules into cowpea mosaic virus-like particles.
Peyret, Hadrien, et al
Recombinant proteins from plants: production and isolation of clinically useful compounds, 103-111 (2022)
Treatment of rifampicin-resistant tuberculosis disease and infection in children: key updates, challenges and opportunities
Howell, Pauline, et al.
Pathogens (Basel, Switzerland), 11.4, 381-381 (2022)

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