SAB5700296

Anti-Phospho-ERBB4-Y1284 antibody produced in rabbit

• Sinónimos: ALS19, ERBB4, HER4, HER4/ErbB4, p180erbB4
• UNSPSC Code: 12352203
• NACRES: NA.43

Propiedades

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 143; 145; 146
• species reactivity: rat, mouse, human
• concentration: 2.55 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: Q15303
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr1284)
• Gene Information: human ... ERBB4(2066)

Descripción

General description

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Immunogen

A synthetic phosphorylated peptide around Y1284 of human ERBB4 (NP_005226.1).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable