SAB2900053

Anti-NR4A1 (AB1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Ngfi-b, gfrp1, nak-1, nak1, nerve growth factor inducible-B protein
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
• UniProt accession no.: P22736
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NR4A1(3164)

Descripción

General description

Nuclear receptor subfamily 4 group A member 1 (NR4A1) is a transcription factor expressed in thymocytes. It is part of an orphan nuclear receptor superfamily. The gene encoding this protein is localized on human chromosome 12.

Immunogen

Synthetic 17 amino acid peptide from internal region of human NUR77. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Horse (100%); Gorilla, Dog, Bat, Panda (94%); Marmoset, Bovine (88%); Mouse, Rat (82%).

Biochem/physiol Actions

Nuclear receptor subfamily 4 group A member 1 (NR4A1) has a role in cell proliferation. It acts as an activator of mechanistic target of rapamycin (mTOR) signaling and regulates apoptosis. The protein modulates genes related to low oxidative stress and growth promotion. NR4A1 has been shown to be expressed in ovarian tumors.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing less than 0.1% sodium azide.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable