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SAB2102574

Sigma-Aldrich

Anti-TRIM8 (ab2) antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Anti-GERP, Anti-RNF27, Anti-Tripartite motif-containing 8

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

61 kDa

species reactivity

pig, rabbit, mouse, bovine, human, rat, dog, horse

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TRIM8(81603)

Immunogen

Synthetic peptide directed towards the middle region of human TRIM8

Biochem/physiol Actions

This protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes.The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes.

Sequence

Synthetic peptide located within the following region: QSVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGE

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Tripartite motif 8 (TRIM8) modulates TNFa- and IL-1?-triggered NF-?B activation by targeting TAK1 for K63-linked polyubiquitination.
Li Q
Proceedings of the National Academy of Sciences of the USA, 108, 19341-19346 (2011)
TRIM8 modulates p53 activity to dictate cell cycle arrest.
Caratozzolo MF
Cell Cycle, 11, 511-523 (2012)
TRIM8/GERP RING finger protein interacts with SOCS-1.
Toniato E
The Journal of Biological Chemistry, 277, 37315-37322 (2002)

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