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Merck
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Key Documents

SAB1409054

Sigma-Aldrich

Monoclonal Anti-FTL antibody produced in mouse

clone X1, purified immunoglobulin, buffered aqueous solution

Sinónimos:

MGC71996

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

X1, monoclonal

form

buffered aqueous solution

mol wt

antigen 44.99 kDa

species reactivity

human

technique(s)

immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

NCBI accession no.

BC004245

UniProt accession no.

P02792

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FTL(2512)

General description

Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. This gene encodes the light subunit of the ferritin protein. It is composed of 24 subunits of the heavy and light ferritin chains.(provided by RefSeq). In humans, the heavy H and the light L chains are made up of 183 and 175 amino acids, respectively. FTL (ferritin) is a heteropolymer, located on human chromosome 19q13. Ferritins centralize iron in their inner compartment as a bioavailable iron oxide biomineral.

Immunogen

FTL (AAH04245, 1 a.a. ~ 175 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKREGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSARTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD

Biochem/physiol Actions

Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.
L-Ferritin subunits deliver the scaffold for a trinuclear peroxo-bridged cluster.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Chemistry at the protein?mineral interface in L-ferritin assists the assembly of a functional (?3-oxo) Tris [(?2-peroxo)] triiron (III) cluster.
Pozzi C, et al.
Proceedings of the National Academy of Sciences of the USA, 114(10), 2580-2585 (2017)
A novel double nucleotide variant in the ferritin-L iron-responsive element in a Finnish patient with hereditary hyperferritinaemia-cataract syndrome
Mattila, et al.
Acta Ophthalmologica, 96(1), 95-99 (2018)
Bjoern Tews et al.
International journal of cancer, 119(4), 792-800 (2006-03-22)
Loss of heterozygosity (LOH) on chromosomal arms 1p and 19q is the most common genetic alteration in oligodendroglial tumors and associated with response to radio- and chemotherapy as well as favorable prognosis. Using microsatellite analysis, we previously identified the chromosomal
Shuping Zhang et al.
Cellular signalling, 26(11), 2539-2550 (2014-08-06)
Iron homeostasis is strictly governed in mammals; however, disordered iron metabolism (such as excess iron burden) is recognized as a risk factor for various types of diseases including cancers. Burgeoning evidence indicates that the central signaling of iron homeostasis, the

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