S101

(R)-(+)-SKF-38393 hydrochloride

≥98% (HPLC), solid

• Fórmula empírica (notación de Hill): C₁₆H₁₇NO₂ · HCl
• Número de CAS: 81702-42-3
• Peso molecular: 291.77
• MDL number: MFCD00055189
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824192
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• optical activity: [α]22/D +16.1°, c = 1.2 in methanol(lit.)
• storage condition: desiccated
• color: off-white to light tan
• solubility: 0.1 M HCl: 1.2 mg/mL; ethanol: 3.4 mg/mL; H₂O: 5 mg/mL; aqueous base: unstable
• SMILES string: Cl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
• InChI: 1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1
• InChI key: YEWHJCLOUYPAOH-PFEQFJNWSA-N

Descripción

Application

(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Biochem/physiol Actions

(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, a benzazepine derivative, exhibits anorectic effects.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Light sensitive

Reconstitution

Solutions may be stored for several days at 4 °C.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves