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S0323

Sematilide monohydrochloride monohydrate

Name: Sematilide monohydrochloride monohydrate
Brand: SIGMA

≥98% (HPLC), powder

Sinónimos:

CK-1752A, N-[2-(Diethylamino)ethyl]-4′-[(methylsulfonyl)amino]benzamide monohydrochloride monohydrate

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About This Item

Fórmula empírica (notación de Hill):

C₁₄H₂₃N₃O₃S· HCl · H₂O

Número de CAS:

101526-62-9

Peso molecular:

367.89

MDL number:

MFCD11041004

UNSPSC Code:

12352200

PubChem Substance ID:

329824420

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H₂O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O.Cl.CCN(CC)CCNC(=O)c1ccc(NS(C)(=O)=O)cc1

InChI

1S/C14H23N3O3S.ClH.H2O/c1-4-17(5-2)11-10-15-14(18)12-6-8-13(9-7-12)16-21(3,19)20;;/h6-9,16H,4-5,10-11H2,1-3H3,(H,15,18);1H;1H2

InChI key

HCGUEOOYHHAYIM-UHFFFAOYSA-N

Biochem/physiol Actions

Sematilide monohydrochloride monohydrate is a class III antiarrhythmic; selective delayed rectifier K+ current (I_Kr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness; shows proarrhythmic effects and may lead to QT interval prolongation.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents.

D S Krafte et al.

Journal of cardiovascular pharmacology, 23(1), 37-41 (1994-01-01)

Voltage-clamp experiments were performed on isolated guinea pig ventricular myocytes to examine the voltage dependence of delayed rectifier block by methanesulfonamide channel blockers. Voltage-dependent channel block, in which block decreases as membrane potential is made more positive, could contribute to

Rate-dependent effects of sematilide on ventricular monophasic action potential duration and delayed rectifier K+ current in rabbits.

G N Beatch et al.

Journal of cardiovascular pharmacology, 28(5), 618-630 (1996-11-01)

Our objective was to define the actions of sematilide in rabbits and to assess the contribution of the delayed rectifier (IK) to rate dependence of action potential duration (APD) in rabbit ventricular myocardium. In studies in vivo, New Zealand White

Pharmacokinetics of sematilide in renal failure.

J Shi et al.

Journal of clinical pharmacology, 36(2), 131-143 (1996-02-01)

A randomized, two-period, two-treatment study was conducted to investigate the effect of renal impairment on the pharmacokinetics of the Class III antiarrhythmic sematilide HCl. The pharmacokinetic-pharmacologic effect relationship and tolerability of sematilide HCl were also studied. The study included 22

Comparison of binding to rapidly activating delayed rectifier K+ channel, IKr, and effects on myocardial refractoriness for class III antiarrhythmic agents.

J J Lynch et al.

Journal of cardiovascular pharmacology, 25(2), 336-340 (1995-02-01)

Saturation binding studies in guinea pig ventricular myocytes with 3H-dofetilide, a radioligand for the cardiac rapidly activating delayed rectifier K+ IKr channel, indicated specific high-affinity binding with a Kd of 83 nM and a Bmax of 0.18 pmol/mg cellular protein

Effects of sematilide, a novel class III antiarrhythmic agent, on action potential in guinea pig atrium.

Y Ishii et al.

Japanese journal of pharmacology, 68(2), 175-182 (1995-06-01)

Electrophysiological effects of sematilide, a novel class III antiarrhythmic agent, were examined and compared with those of (+/-)sotalol in guinea pig left atrium by a conventional microelectrode technique. Application of 0.1-1000 microM sematilide or 1-1000 microM (+/-)sotalol concentration-dependently prolonged the

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