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Key Documents

PRS2265

Sigma-Aldrich

Anti-Nephrin antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

CNF, NPHN, Renal glomerulus-specific cell adhesion receptor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NPHS1(4868)

Categorías relacionadas

General description

Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. It is a 1241-residue transmembrane protein. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomalrecessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm.

Immunogen

Nephrin antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human
Nephrin. The immunogen is located within the last 50 amino acids of Nephrin.

Linkage

The action of this antibody can be blocked using blocking peptide SBP2265.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Positionally Cloned Gene for a Novel Glomerular Protein?Nephrin?Is Mutated in Congenital Nephrotic Syndrome
Marjo Kestilla
Molecular Cell, 1(4), 575-582 (1998)
Balajikarthick Subramanian et al.
Kidney international, 90(2), 363-372 (2016-06-29)
Mutations in the INF2 (inverted formin 2) gene, encoding a diaphanous formin family protein that regulates actin cytoskeleton dynamics, cause human focal segmental glomerulosclerosis (FSGS). INF2 interacts directly with certain other mammalian diaphanous formin proteins (mDia) that function as RhoA
Xiao-Yu Lu et al.
American journal of physiology. Renal physiology, 317(6), F1605-F1611 (2019-10-01)
The transient receptor potential canonical 6 (TRPC6) channel and podocin are colocalized in the glomerular slit diaphragm as an important complex to maintain podocyte function. Gain of TRPC6 function and loss of podocin function induce podocyte injury. We have previously
Alexander Lehners et al.
American journal of physiology. Renal physiology, 307(4), F407-F417 (2014-07-06)
Myeloperoxidase (MPO) is an enzyme expressed in neutrophils and monocytes/macrophages. Beside its well-defined role in innate immune defence, it may also be responsible for tissue damage. To identify the role of MPO in the progression of chronic kidney disease (CKD)
Dong Wang et al.
International journal of molecular sciences, 19(1) (2018-01-06)
Obesity and obesity related kidney and liver disease have become more prevalent over the past few decades, especially in the western world. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of antidiabetic agents with promising effects on cardiovascular and

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