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P9607

Sigma-Aldrich

Anti-Potassium Channel Kv2.1 (DRK1) antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

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About This Item

MDL number:
MFCD01633584
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:250-1:500

UniProt accession no.

P15387

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCNB1(3745)
mouse ... Kcnb1(16500)
rat ... Kcnb1(25736)

Immunogen

synthetic peptide corresponding to amino acids 837-853 of rat potassium channel Kv2.1 (with an additional N-terminal cysteine and tyrosine).The epitope is identical in mouse and rat and highly homologous in human and pig.

Physical form

Lyophilized at ∼1 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.05% sodium azide.

Preparation Note

Protein A purified.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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J S Trimmer
Proceedings of the National Academy of Sciences of the United States of America, 88(23), 10764-10768 (1991-12-01)
Antibodies specific for the drk1 polypeptide were used to characterize the corresponding protein in rat brain. Recombinant and synthetic immunogens containing fragments of the drk1 polypeptide were produced. Antibodies raised to these immunogens display monospecific reactions with the same 130-kDa
G Shi et al.
The Journal of biological chemistry, 269(37), 23204-23211 (1994-09-16)
We have transiently expressed the rat Kv2.1 K+ channel polypeptide (pKv2.1) at high levels by transfection of mammalian COS-1 cells. Kv2.1-transfected cells express a molecular mass of 108 kDa pKv2.1, larger than the size of the core polypeptide (95 kDa)
G C Frech et al.
Nature, 340(6235), 642-645 (1989-08-24)
Voltage-activated potassium channels play an important part in the control of excitability in nerve and muscle. Different K+ channels are involved in establishing the resting potential, determining the duration of action potentials, modulation of transmitter release, and in rhythmic firing
P M Hwang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(4), 1569-1576 (1993-04-01)
We have localized CDRK and DRK1, two novel K+ channels of the Shab subfamily by immunohistochemistry. The two channels are closely related in structure with about 90% amino acid identity in the N-terminal and middle portions and 60% identity in
Marjaana A Peltola et al.
EMBO reports, 12(12), 1293-1299 (2011-11-08)
Kv2.1 is a potassium channel α-subunit abundantly expressed throughout the brain. It is a main component of delayed rectifier current (I(K)) in several neuronal types and a regulator of excitability during high-frequency firing. Here we identify AMIGO (amphoterin-induced gene and
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