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Merck
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Key Documents

P6902

Sigma-Aldrich

Pheniramine maleate salt

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About This Item

Fórmula empírica (notación de Hill):
C16H20N2 · C4H4O4
Número de CAS:
132-20-7
Peso molecular:
356.42
EC Number:
205-051-4
MDL number:
MFCD00079250
UNSPSC Code:
12352116
PubChem Substance ID:
24277769
NACRES:
NA.77

form

powder

SMILES string

OC(=O)\C=C/C(O)=O.CN(C)CCC(c1ccccc1)c2ccccn2

InChI

1S/C16H20N2.C4H4O4/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16;5-3(6)1-2-4(7)8/h3-10,12,15H,11,13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

SSOXZAQUVINQSA-BTJKTKAUSA-N

Gene Information

human ... HRH1(3269)

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Biochem/physiol Actions

Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Giuseppina Ioele et al.
Chemical & pharmaceutical bulletin, 59(1), 35-40 (2011-01-08)
A chemometric approach based on the combined use of the principal component analysis (PCA) and artificial neural network (ANN) was developed for the multicomponent determination of caffeine (CAF), mepyramine (MEP), phenylpropanolamine (PPA) and pheniramine (PNA) in their pharmaceutical preparations without
Kerem Karaman et al.
American journal of surgery, 205(2), 213-219 (2012-09-05)
Laparoscopic cholecystectomy (LC) still leads to significant postoperative nausea and vomiting (PONV) and pain. Our aim was to evaluate the efficacy of dexamethasone or pheniramine hydrogen maleate, either alone or combined, in reducing the stress response and symptoms after LC.
Wenhua Gao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 904, 121-127 (2012-08-21)
A rapid and efficient dual preconcentration method of on-line single drop liquid-liquid-liquid microextraction (SD-LLLME) coupled to sweeping micellar electrokinetic chromatography (MEKC) was developed for trace analysis of three antihistamines (mizolastine, chlorpheniramine and pheniramine) in human urine. Three analytes were firstly
M R Louhaichi et al.
Talanta, 78(3), 991-997 (2009-03-10)
A new simple, rapid and sensitive liquid chromatographic method has been developed and validated for the simultaneous determination of pseudoephdrine, pheniramine, guaifenisin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold pharmaceuticals. The separation of these compounds was achieved within 13
Ana B Guimaraes-Correa et al.
Viruses, 3(7), 1041-1058 (2011-10-14)
Adult T-cell leukemia/lymphoma (ATLL) is a highly aggressive disease that occurs in individuals infected with the human T lymphotropic virus type 1 (HTLV-1). Patients with aggressive ATLL have a poor prognosis because the leukemic cells are resistant to conventional chemotherapy.
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