NCSTUD002

MISSION^® Synthetic microRNA Inhibitor

cel-miR-243-3p, Negative Control 2, Sequence from Caenorhabditis elegans with no homology to human and mouse gene sequences

• Sinónimos: Synthetic Tough Decoy, sTuD
• UNSPSC Code: 41105324
• NACRES: NA.51

Propiedades

• product line: MISSION^®
• form: solid
• mature sequence: CGGUACGAUCGCGGCGGGAUAUC
• Sanger mature/minor accession no.: MIMAT0000299
• Sanger microRNA accession no.: MI0000319
• storage temp.: −20°C

Descripción

General description

Individual synthetic microRNA inhibitors were designed using a proprietary algorithm, which is based on the work of Haraguchi, T, et al. and in collaboration with Dr. Hideo Iba, University of Tokyo.† This algorithm utilizes the tough decoy (TuD) design. miRNA are known to regulate gene expression in a variety of manners, including translational repression, mRNA cleavage and deadenylation.

The MISSION synthetic miRNA Inhibitors are small, double-stranded RNA molecules designed to inhibit a specific mature miRNA. The miRNA inhibitors were designed using the mature miRNA sequence information from miRBase and are 2′-O-methylated RNA duplexes with a miRNA binding site on each strand. Optimal miRNA inhibition is provided after transfection due to the robust secondary structure of the inhibitor.

• Long lasting inhibition at very low dosage
• Excellent resistance to cellular nucleases
• Custom synthesis available for a variety of species

Other Notes

Based on miRBase V19

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS08
• signalword: Warning
• hcodes: H373
• pcodes: P260 - P314 - P501
• Hazard Classifications: STOT RE 2 Inhalation
• target_organs: Respiratory Tract
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable