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Merck

N8133

Sigma-Aldrich

Nerve Growth Factor from Vipera lebetina venom

NGF, lyophilized powder, suitable for cell culture

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About This Item

Número de CAS:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

Vipera Lebetina

Quality Level

form

lyophilized powder

potency

0.2-20 μg/mL ED50/EC50

quality

endotoxin tested

mol wt

protein 32.5 kDa

packaging

pkg of 0.1 mg

technique(s)

cell culture | mammalian: suitable

impurities

<10 EU/vial

color

white to off-white

UniProt accession no.

storage temp.

−20°C

Physical form

Lyophilized from a 0.2 μm filtered solution in sodium acetate buffer.

Preparation Note

Isolated from the snake venom of V. lebetina.

Analysis Note

The biological activity of Nerve Growth Factor (NGF) from Vipera lebetina venom is measured in a cell proliferation assay using PC-12 cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Trk neurotrophin receptor ubiquitination in response to ligand activation regulates signaling, trafficking, and degradation of the receptors. However, the in vivo consequences of Trk ubiquitination remain to be addressed. We have developed a mouse model with a mutation in the
Federica De Angelis et al.
Journal of cellular physiology, 229(6), 783-790 (2013-10-30)
The peripheral application of the M2 cholinergic agonist arecaidine on sensory nerve endings shows anti-nociceptive properties. In this work, we analyze in vitro, the mechanisms downstream M2 receptor activation causing the analgesic effects, and in vivo the effects produced by
Yu-Jung Chang et al.
Biochimica et biophysica acta, 1830(8), 4130-4136 (2013-04-16)
Neurotrophins are important regulators for neural development and regeneration. Nerve growth factor (NGF) therapy has been tested in various models of neural injury and degeneration. However, whether NGF can reach target tissues and maintain effective concentration for a certain period
M Florencia Iulita et al.
Trends in pharmacological sciences, 35(7), 338-348 (2014-06-26)
Alzheimer's disease (AD) is a devastating neurodegenerative condition and the most common type of amnestic dementia in the elderly. Individuals with Down syndrome (DS) are at increased risk of developing AD in adulthood as a result of chromosome 21 trisomy

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