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N4751

Sigma-Aldrich

Nicotinuric acid

Sinónimos:

Nicotinylglycine

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About This Item

Fórmula empírica (notación de Hill):
C8H8N2O3
Número de CAS:
583-08-4
Peso molecular:
180.16
EC Number:
209-497-0
MDL number:
MFCD00023578
UNSPSC Code:
12352106
PubChem Substance ID:
24897709
NACRES:
NA.79

assay

≥98% (with NaOH, titration)

form

powder

color

white

SMILES string

OC(=O)CNC(=O)c1cccnc1

InChI

1S/C8H8N2O3/c11-7(12)5-10-8(13)6-2-1-3-9-4-6/h1-4H,5H2,(H,10,13)(H,11,12)

InChI key

ZBSGKPYXQINNGF-UHFFFAOYSA-N

Categorías relacionadas

Biochem/physiol Actions

Nicotinuric acid (NUA) is a metabolite of niacin/vitamin B. Measurement of NUA levels in urine is used to indicate possible elevated nicotinamide adenine dinucleotide (NAD) catabolism. NUA may be used as a reference (standard curve) in the analysis of NAD and NUA catabolism. Nicotinic acid reduces triglycerides and increases high density lipoprotein(HDL) cholesterol.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Effect of Nicotinic Acid (Vitamin B3 or Niacin) on the lipid profile of diabetic and non-diabetic rats
Shah TZ, et al.
Pakistan Journal of Medical Sciences, 29(5), 1259-1259 (2013)
H L Figge et al.
Journal of clinical pharmacology, 28(12), 1136-1140 (1988-12-01)
We tested an inexpensive controlled-release nicotinic acid product (Bronson Pharmaceuticals, LaCanada, CA) and compared it with the standard, more expensive, controlled release product, Nicobid (Rorer Pharmaceuticals), by measuring the 24 hour urinary recovery of nicotinic and nicotinuric acids from ten
P J Neuvonen et al.
British journal of clinical pharmacology, 32(4), 473-476 (1991-10-01)
1. The bioavailability of three nicotinic acid formulations was investigated in a randomized cross-over study. 2. Single doses of nicotinic acid (500 mg) were given to seven healthy volunteers. The concentrations of nicotinic acid and its main metabolite nicotinuric acid
High-performance liquid chromatographic determination of nicotinic acid and its metabolites, nicotinuric acid and nicotinamide, in plasma.
K Takikawa et al.
Journal of chromatography, 233, 343-348 (1982-12-10)
R H Stern et al.
Clinical pharmacology and therapeutics, 50(1), 66-70 (1991-07-01)
The mechanism of tolerance to nicotinic acid flushing was determined in subjects during a 5-day course of treatment. Objective measures of skin blood flow were used to confirm the development of tolerance. Plasma levels of nicotinic acid showed marked intraindividual
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