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Merck

M8890

Sigma-Aldrich

Anti-Mouse IgG (whole molecule) antibody produced in goat

IgG fraction of antiserum, lyophilized powder

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About This Item

EC Number:
MDL number:
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

goat

Quality Level

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

secondary antibodies

clone

polyclonal

form

lyophilized powder

packaging

vial of 2 mL lyophilized antiserum

technique(s)

Ouchterlony double diffusion: 1:8

storage temp.

2-8°C

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Application

Anti-Mouse IgG (whole molecule) antibody produced in goat was used to immunoprecipitate bovine brain adenylyl cyclase. It was used α-defensin isoforms in the plasma of type I diabetic patients by radio immune assay.

Biochem/physiol Actions

IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.

Physical form

Lyophilized from 0.01 M phosphate buffered saline, pH 7.2

Reconstitution

Reconstitute with 2 mL deionized water.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Gowsini Joseph et al.
The Journal of clinical endocrinology and metabolism, 93(4), 1470-1475 (2008-01-24)
alpha-Defensins are antimicrobial peptides of the innate immune system. In addition, experimental evidence suggests that alpha-defensins are proatherogenic. The objective of the study was to examine the predictive value of plasma alpha-defensin as a clinical marker of cardiovascular disease (CVD)
S Mollner et al.
European journal of biochemistry, 171(1-2), 265-271 (1988-01-15)
Four monoclonal antibodies, raised against the 115-kDa adenylyl cyclase from bovine brain [Pfeuffer, E. et al. (1985) EMBO J. 4, 3675-3679] have been selected and designated BBC-1 to BBC-4. BBC-1 and BBC-3 are highly specific for the 115-kDa enzyme from
Julius Grzeschik et al.
Biotechnology journal, 14(4), e1800466-e1800466 (2018-10-24)
Yeast surface display emerged as a viable tool for the generation of human and murine monoclonal antibodies. This platform technology enables the careful definition of selection conditions, the potential for high-throughput screening, as well as the isolation of antibodies recognizing
L L Peters et al.
Blood, 76(4), 745-754 (1990-08-15)
A new autosomal recessive mouse mutation, scat (severe combined anemia and thrombocytopenia), causes intermittent episodes of severe bleeding in the homozygote. At birth, affected mice are pale with intradermal petechiae and bruises on exposed surfaces. Central nervous system (CNS) bleeding
M Saraheimo et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 23(3), 914-918 (2007-11-16)
Diabetic nephropathy is associated with low-grade inflammation and activation of the complement system. Defensins, as part of the innate immune system, may play a regulatory role in the complement cascade and may also augment the production of proinflammatory cytokines. The

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