M5060

E-4031

≥98% (HPLC), lyophilized powder

• Sinónimos: N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
• Fórmula empírica (notación de Hill): C₂₁H₂₇N₃O₃S · 2HCl
• Número de CAS: 113559-13-0
• Peso molecular: 474.44
• MDL number: MFCD01754739
• UNSPSC Code: 12352207
• PubChem Substance ID: 329818000
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: lyophilized powder
• storage condition: desiccated
• technique(s): cell culture | embryo: suitable
• color: white
• solubility: H₂O: soluble
• storage temp.: −20°C
• SMILES string: Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c3ccc(NS(C)(=O)=O)cc3)n1
• InChI: 1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H
• InChI key: ZQBNWMFBOSOOLX-UHFFFAOYSA-N

Descripción

Application

E-4031 has been used as:

• human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
• IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
• IKr blocker in rat ventricular myocytes

Biochem/physiol Actions

E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.

E-4031 selectively blocks hERG K⁺ channels.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)