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Merck
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Key Documents

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M4773

Sigma-Aldrich

Metaraminol (+)-bitartrate salt

Sinónimos:

(−)-m-Hydroxyphenylpropanolamine bitartrate salt

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About This Item

Fórmula empírica (notación de Hill):
C9H13NO2 · C4H6O6
Número de CAS:
33402-03-8
Peso molecular:
317.29
EC Number:
251-502-3
MDL number:
MFCD00238763
UNSPSC Code:
12352200
PubChem Substance ID:
24896944
NACRES:
NA.77

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.C[C@H](N)[C@H](O)c1cccc(O)c1

InChI

1S/C9H13NO2.C4H6O6/c1-6(10)9(12)7-3-2-4-8(11)5-7;5-1(3(7)8)2(6)4(9)10/h2-6,9,11-12H,10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t6-,9-;1-,2-/m01/s1

InChI key

VENXSELNXQXCNT-IJYXXVHRSA-N

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Application

Metaraminol (+)-bitartrate salt has been used to study the effects of adrenergic agonists in the mouse model of endometriosis.

Biochem/physiol Actions

α-adrenoceptor agonist.
Metaraminol may serve as a false sympathetic transmitter. It is a mixed α - and β-adrenergic agonist.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

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Studies on the interrelationship between the syntheses of noradrenaline and metaraminol
Johnson GE and Pugsley TA
British Journal of Pharmacology, 39(1), 167-174 (1970)
J Tanaka et al.
Experimental neurology, 152(2), 303-306 (1998-08-26)
To verify whether noradrenergic inputs to the subfornical organ (SFO) are involved in the control system of arterial pressure, we investigated the effects of blood pressure changes on noradrealine (NA) release in the SFO and its surrounding sites using microdialysis
Einly Lim et al.
Artificial organs, 36(5), E110-E124 (2012-04-12)
A heart-pump interaction model has been developed based on animal experimental measurements obtained with a rotary blood pump in situ. Five canine experiments were performed to investigate the interaction between the cardiovascular system and the implantable rotary blood pump over
Impact of admixture time and diluent order on metaraminol concentration.
J N Darvall et al.
Anaesthesia and intensive care, 37(5), 859-860 (2009-09-25)
Marilyn P Law et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 51(8), 1269-1276 (2010-08-04)
Dysfunction of the sympathetic nervous system underlies many cardiac diseases and can be assessed by molecular imaging using PET in humans. Small-animal PET should enable noninvasive quantitation of the sympathetic nervous system in mouse models of human disease. For mice
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