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Key Documents

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I2633

Sigma-Aldrich

Cardiogreen

Powder

Sinónimos:

Foxgreen, IC Green, Indocyanine green

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About This Item

Fórmula empírica (notación de Hill):
C43H47N2NaO6S2
Número de CAS:
3599-32-4
Peso molecular:
774.96
Beilstein/REAXYS Number:
4115884
EC Number:
222-751-5
MDL number:
MFCD00013078
UNSPSC Code:
12171500
PubChem Substance ID:
24895979
NACRES:
NA.47

product name

Cardiogreen, polymethine dye

Quality Level

200

form

powder

composition

Dye content, ≥75%

technique(s)

titration: suitable

color

green to very dark green

solubility

water: 0.01 g/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].CC1(C)/C(=C\C=C\C=C\C=C\C2=[N+](CCCCS([O-])(=O)=O)c3ccc4ccccc4c3C2(C)C)N(CCCCS([O-])(=O)=O)c5ccc6ccccc6c15

InChI

1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1

InChI key

MOFVSTNWEDAEEK-UHFFFAOYSA-M

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General description

Cardiogreen is a negatively charged polymethine dye that forms noncovalent fluorescent complexes with proteins. This "pseudofluorogenic" property has been utilized for protein determination by capillary electrophoresis with diode laser-induced fluorescence detection.

Application

Cardiogreen has been used to resolve several labeled proteins including: human serum albumin, ribonuclease A, transferrin, and cytochrome c.
Cardiogreen has been used as an intraocular capsular stain. It has been used in the dye-dilution method for cardiac output.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

solubility: 0.01g in 10mL H2O : green to very dark green

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats.
Irwin D et al.
American Journal of Respiratory Cell and Molecular Biology, 42, 200-200 (2010)
Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes.
Huang AS et al.
Translational vision science & technology, 5, 5-5 (2016)
E M McCorquodale et al.
Electrophoresis, 22(12), 2403-2408 (2001-08-25)
Indocyanine green (ICG)--a negatively charged, polymethine dye--can interact noncovalently with proteins to form fluorescent complexes, with excitation and emission maxima near 780 and 820 nm, respectively. This behavior was realized utilizing either a 100 mM phosphate buffer or a 25
Hisako Hara et al.
Plastic and reconstructive surgery, 132(6), 1612-1618 (2013-09-06)
The authors investigated the relationship between findings from indocyanine green lymphography and the condition of lymphatics according to the Normal, Ectasis, Contraction, Sclerosis Type classifications observed in each area during surgery. The authors examined 43 limbs of 25 patients who
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The British journal of surgery, 100(8), 1037-1044 (2013-05-23)
Combining radioactive colloids and a near-infrared (NIR) fluorophore permits preoperative planning and intraoperative localization of deeply located sentinel lymph nodes (SLNs) with direct optical guidance by a single lymphatic tracer. The aim of this clinical trial was to evaluate and
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