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H4126

Sigma-Aldrich

Hydrocortisone 21-acetate

≥98% (HPLC)

Sinónimos:

11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-acetate, 17-α-Hydroxycorticosterone acetate, 17-Hydroxycorticosterone 21-acetate, 21-Acetoxy-4-pregnene-11β,17α-diol-3,20-dione, 4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate

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About This Item

Fórmula empírica (notación de Hill):
C23H32O6
Número de CAS:
50-03-3
Peso molecular:
404.50
Beilstein/REAXYS Number:
2066841
EC Number:
200-004-4
MDL number:
MFCD00037714
UNSPSC Code:
12352200
PubChem Substance ID:
24895620
NACRES:
NA.77

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

technique(s)

permeability assay: suitable

mp

223 °C (dec.) (lit.)

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

Gene Information

human ... NR3C1(2908) , SERPINA6(866)

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General description

Hydrocortisone 21-acetate is an adrenocortical steroid. Hydrocortisone acts as an immunosuppressive drug and might suppress systemic inflammatory responses. It is used to treat rheumatoid arthritis and adrenal insufficiency. It also functions as an antiallergic agent.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Repr. 1B - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Holger P Behrsing et al.
Toxicological sciences : an official journal of the Society of Toxicology, 131(2), 470-479 (2012-11-13)
The anticancer drug (2-[4-amino-3-methylphenyl]-5-fluorobenzothiazole lysylamide dihydrochloride) (NSC 710305, Phortress) is a metabolically activated prodrug that causes DNA adduct formation and subsequent toxicity. Preclinically, it was found that hepatic, bone marrow, and pulmonary toxicity presented challenges to developing this drug. An
Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production
Attur MG, et al.
Inflammation Research, 49(1), 20-26 (2000)
Adrenal insufficiency in patients with cirrhosis and septic shock: effect of treatment with hydrocortisone on survival
Fernandez J, et al.
Hepatology, 44(5), 1288-1295 (2006)
Hydrocortisone and cortisone injected into arthritic joints: comparative effects of and use of hydrocortisone as a local antiarthritic agent
Hollander JL, et al.
Journal of the American Medical Association, 147(17), 1629-1635 (1951)
The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies, 20-26 (2014)
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