H1753

Hydralazine hydrochloride

• Sinónimos: 1-Hydrazinophthalazine hydrochloride
• Fórmula empírica (notación de Hill): C₈H₈N₄ · HCl
• Número de CAS: 304-20-1
• Peso molecular: 196.64
• EC Number: 206-151-0
• MDL number: MFCD00135998
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278461
• NACRES: NA.77

Propiedades

• biological source: synthetic (organic)
• Quality Level: 100
• assay: ≥99% (TLC)
• form: powder
• mp: 273 °C
• solubility: water: 50 mg/mL
• SMILES string: Cl[H].N\N=C1/N=NC=C2C=CC=CC12
• InChI: 1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;
• InChI key: SECXUXOCDLQOBI-MKFZHGHUSA-N
• Gene Information: human ... MAOA(4128) , MAOB(4129)

Descripción

Application

Hydralazine hydrochloride has been used:

• as a vasodilator to study its effects on hypertension in T-cell frequencies in juvenile rats
• as a semicarbazide-sensitive amine oxidase (SSAO) inhibitor to study its effects on myocardial ischemia-reperfusion (I/R) injury
• as a vasodilator to study its effects on insulin secretion and glucose tolerance

Biochem/physiol Actions

Hydralazine hydrochloride has therapeutic effects against heart failure and high blood pressure.

Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Non-selective MAO-A/B inhibitor; antihypertensive; semicarbazide-sensitive amine oxidase inhibitor.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H315,H319,H335
• pcodes: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves