G5640

Globulins Cohn fraction II, III from goat

• Sinónimos: Vitamin D binding protein
• Número de CAS: 68476-36-8
• EC Number: 270-678-2
• MDL number: MFCD00164084
• UNSPSC Code: 12352202
• NACRES: NA.61

Propiedades

• biological source: goat
• assay: 73-90% protein basis (biuret)
• form: lyophilized powder
• composition: Protein, 73-90% biuret
• solubility: H₂O: soluble 25 mg/mL
• storage temp.: 2-8°C

Descripción

General description

Vitamin D binding protein (DBP) is a polymorphic protein that specifically binds to vitamin D and its metabolites. This protein belongs to the albuminoid family and is highly conserved among vertebrates. The gene encoding DBP is mapped to human chromosome 4q11-q13. It is predominantly produced in the liver and is also expressed in the kidney, endocrine pancreatic cells, fat cells, and testis.

Application

Globulins were used in Biotin/avidin formulations.

Biochem/physiol Actions

Vitamin D binding protein (DBP) specifically binds and transports vitamin D and its metabolites with high affinity. It promotes fibrillar actin clearance by binding to actin monomers. DBP also binds to unsaturated fatty acids, megalin-cubilin receptor complex, the membrane of leukocytes, and the activation of the complement C5 system. The levels of DBP indicate the free concentration of all vitamin D metabolites. Decreased levels of serum DBP are observed in liver diseases, nephrotic syndrome, malnutrition, severe acute trauma, or disease.

Other Notes

Primarily γ-globulins

Physical form

Lyophilized powder containing NaCl

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable