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Key Documents

E6402

Sigma-Aldrich

Elastin from mouse lung

powder

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About This Item

Número de CAS:
9007-58-3
EC Number:
232-701-4
MDL number:
MFCD03456696
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

mouse lung

Quality Level

100

form

powder

UniProt accession no.

P54320

storage temp.

2-8°C

InChI

1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1

InChI key

DPUYCSDGMSDKKV-MKBYFEBXSA-N

Gene Information

mouse ... Eln(13717)

General description

Elastin is a key protein of the extracellular matrix (ECM). It is made up of glycoproteins, glycosaminoglycans, collagen and proteoglycans. Elastin is mainly localized in the arteries and lungs.
Elastin is an important extracellular matrix (ECM) protein derived from its precursor tropoelastin. Elastin is highly flexible than collagen.

Application

Elastin mouse lung has been used as an extracellular matrix (ECM) protein for coating of plates.

Biochem/physiol Actions

Elastin delivers elasticity to tissues and organs. In addition, it is also involved in paracrine signaling. Genetic variation in the gene coding for elastin causes Williams-Beuren syndrome, cutis laxa and supravalvular aortic stenosis (SVAS).
Elastin plays a critical role in alveolization in the fetal lung. In vivo radiochemical labelling indicates that mouse or rat lung elastin is synthesized primarily prenatally and during the first two weeks of life. It turns over very slowly, with a half-life estimated at several years.
Elastin plays an important role in the elasticity and resilience of many tissues, such as ligament, tendon and elastic cartilage. It is also involved in the elasticity of large arteries and skin.

Preparation Note

Purified under mild extraction conditions to minimize peptide bond cleavage as described by Starcher, et al.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Yulian Wang et al.
Journal of visualized experiments : JoVE, (60) (2012-03-01)
Mechanical forces generated in utero by repetitive breathing-like movements and by fluid distension are critical for normal lung development. A key component of lung development is the differentiation of alveolar type II epithelial cells, the major source of pulmonary surfactant.
Karolina Chrabaszcz et al.
Cancers, 13(2) (2021-01-10)
The current understanding of mechanisms underlying the formation of metastatic tumors has required multi-parametric methods. The tissue micro-environment in secondary organs is not easily evaluated due to complex interpretation with existing tools. Here, we demonstrate the detection of structural modifications
Jiří Kanta
Frontiers in physiology, 7, 491-491 (2016-11-09)
A characteristic feature of liver cirrhosis is the accumulation of large amounts of connective tissue with the prevailing content of type I collagen. Elastin is a minor connective tissue component in normal liver but it is actively synthesized by hepatic
Elastin in the Liver
Kanta J.
Frontiers in Physiology, 7, 491-491 (2016)
An experimental system to study mechano transduction in fetal lung cells
Wang Y, et al.
Journal of Visualized Experiments, 7(60), e3543-e3543 (2012)
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