D6946

(R)-DRF053 hydrochloride hydrate

≥98% (HPLC)

• Sinónimos: 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]- 9H-purin-2-yl]amino]-1-butanol hydrochloride hydrate
• Fórmula empírica (notación de Hill): C₂₃H₂₇N₇O · xHCl · yH₂O
• Peso molecular: 417.51 (anhydrous free base basis)
• MDL number: MFCD17215921
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798839
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: ≥30 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.Cl.CC[C@H](CO)Nc1nc(Nc2cccc(c2)-c3ccccn3)c4ncn(C(C)C)c4n1
• InChI: 1S/C23H27N7O.ClH.H2O/c1-4-17(13-31)27-23-28-21(20-22(29-23)30(14-25-20)15(2)3)26-18-9-7-8-16(12-18)19-10-5-6-11-24-19;;/h5-12,14-15,17,31H,4,13H2,1-3H3,(H2,26,27,28,29);1H;1H2/t17-;;/m1../s1
• InChI key: ZOSNTFVWVJFXQO-ZEECNFPPSA-N

Descripción

Biochem/physiol Actions

DRF053 is a more potent version of roscovitine. It is 2 fold more potent against CDK5 (80 nM) and over 150 times more potent against CDK1 (14 nM).

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable