D0447

D12-116 trifluoroacetate salt

≥98% (HPLC), powder

• Sinónimos: L-Tyrosyl-L-a-glutamyl-L-seryl-L-isoleucyl-L-arginyl-L-isoleucylglycyl-L-valyl-L-alanyl-L-prolyl-L-seryl-L-glutamine trifluoroacetate salt, YESIRIGVAPSQ trifluoroacetate salt
• Fórmula empírica (notación de Hill): C₅₈H₉₄N₁₆O₁₉ · xC₂HF₃O₂
• Peso molecular: 1319.46 (free base basis)
• MDL number: MFCD23380197
• UNSPSC Code: 12352203
• PubChem Substance ID: 329798609
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: H₂O: ≥2 mg/mL
• storage temp.: −20°C
• SMILES string: OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(O)=O
• InChI: 1S/C58H94N16O19.C2HF3O2/c1-8-29(5)45(53(88)64-25-42(79)71-44(28(3)4)54(89)65-31(7)56(91)74-23-11-13-40(74)52(87)70-38(26-75)50(85)68-37(57(92)93)18-20-41(60)78)72-49(84)35(12-10-22-63-58(61)62)67-55(90)46(30(6)9-2)73-51(86)39(27-76)69-48(83)36(19-21-43(80)81)66-47(82)34(59)24-32-14-16-33(77)17-15-32;3-2(4,5)1(6)7/h14-17,28-31,34-40,44-46,75-77H,8-13,18-27,59H2,1-7H3,(H2,60,78)(H,64,88)(H,65,89)(H,66,82)(H,67,90)(H,68,85)(H,69,83)(H,70,87)(H,71,79)(H,72,84)(H,73,86)(H,80,81)(H,92,93)(H4,61,62,63);(H,6,7)/t29-,30-,31-,34-,35-,36-,37-,38-,39-,40-,44-,45-,46-;/m0./s1
• InChI key: UVRSGFIIMHKCQD-ASTQSYHGSA-N

Descripción

Biochem/physiol Actions

D12-116 is a specific allosteric modulator of the glycine receptor (GlyR). The peptide D12-116 produces a marked enhancement of GlyR function while not affecting a1b2g2S GABAA receptors.

Features and Benefits

This compound is featured on the Glycine Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable