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C8180

Sigma-Aldrich

Cholera Toxin A Subunit from Vibrio cholerae

lyophilized powder

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About This Item

MDL number:
MFCD00130777
UNSPSC Code:
12352200
NACRES:
NA.77

form

lyophilized powder

Quality Level

200

composition

Protein, ~5% Lowry

availability

not available in Japan

impurities

≤0.5% Cholera toxin B subunit (SDS-PAGE)

storage temp.

2-8°C

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General description

Cholera Toxin (CT) is secreted by Vibrio cholerae. CT upregulates cell surface molecules, such as co-stimulatory molecules and chemokine receptors in antigen presenting cells(APCs), murine and human dendritic cells (DCs). It enhances the secretion of interleukin 1 (IL-1) from macrophages and stimulates their APC function. CT also functions as an immunomodulator.

Application

Cholera Toxin A Subunit from Vibrio cholerae has been used as a specific probe for trimeric G proteins in membrane motility assays.

Biochem/physiol Actions

Catalyzes ADP-ribosylation of the α-subunit of G proteins, reducing GTPase activity and activating the α-subunit; also catalyzes ADP-ribosylation of cell membrane adenylyl cyclase

Physical form

Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide and sodium EDTA

Reconstitution

When reconstituted with 1 mL of water, the solution will contain 0.05 M Tris buffer salts, pH 7.5, 0.2 M NaCl, 0.003 M NaN3, and 0.001 M sodium EDTA. Store reconstituted solutions in the refrigerator.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H332,H412

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Actions of cholera toxin and the prevention and treatment of cholera
Holmgren J.
Nature, 292(5822), 413-413 (1981)
In Vitro Reconstitution of Microtubule Plus End-directed, GTPgammaS-sensitive Motility of Golgi Membranes
Fullerton AT, et al.
Molecular Biology of the Cell, 9(10), 2699-2714 (1998)
Cholera toxin: a paradigm of a multifunctional protein
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